Topic: Activity-dependent myelination

Learning relies as much on synaptic weight modifications as it does on the timing of neural signaling. For instance, variability in axonal length and diameter may compromise spike-timing-dependent plasticity (STDP) by dispersing action potential timing, preventing synaptic potentiation and depression. Activity-dependent myelination (ADM), a form of brain plasticity relying on neuron-glia feedback, has been shown to normalize conduction times across different axons through adaptive, neuron-activity-dependent changes in axonal conduction velocity (CV). While historically seen as a mere compensat

Focal cortical dysplasia (FCD) is a regional malformation of cortical development frequently associated with pharmacoresistant epilepsy. It is caused by somatic mutations affecting the mTOR signaling pathway within excitatory neurons. At the cellular level, FCD manifests as the emergence of dysmorphic neurons, disrupted neuronal migration, and consequent alterations in neuronal circuitry, accompanied by seizure occurrence. It has been demonstrated that physiological neuronal activity stimulates oligodendrocyte lineage cells (OLCs) to proliferate, differentiate, and myelinate. We hypothesize th