Topic: adiponectin

Cerebrovascular damage and dysfunction have been suggested to be closely related to pathophysiology of Alzheimer's disease (AD). The effect of adiponectin (APN), an adipocyte-secreted hormone, on the risk and progression of AD patients remains unclear. APN has been demonstrated to play a protective role in peripheral vasculature, while little is known about its impact on cerebrovascular dysfunction in AD. In this study, we examined the cerebrovascular integrity of wildtype, 5xFAD, APN knockout (APN-/-), and APN-deficient 5xFAD (5xFAD;APN-/-) mice in terms of blood-brain barrier (BBB) permeabil

The escalating global obesity epidemic underscores the need to understand its intricate health implications. Research highlights associations between elevated body mass index (BMI) and structural changes in both white and gray matter (WM, GM). Given the indirect nature of BMI as an indicator of adiposity, a comprehensive evaluation of body composition becomes essential. This study explores distinct adipose tissue compartments, adipokine levels, and their interplay with structural alterations in both WM and GM, elucidating the complex relationship between obesity, brain structure, and metabolic