Topic: adult mice

Normal aging is characterized by a decline in several cognitive faculties, including the ability to adapt behavior in response to changing environmental contingencies.This ability, known as behavioral flexibility (BF) can be examined by the attentional set-shifting task (ASST), which has been used in rodent to evaluate cognitive impairment involving dysfunction in the prefrontal cortex (PFC), a core feature of several neuropsychiatric disorders. However, this test has not been used to assess BF in aged mice.We evaluated and compared BF between adult and aged mice with the ASST. Here, rodents l

This study was undertaken to assess sex differences in the vicarious learning magnitude by exploiting an aversive paradigm in adult mice. Mouse observers were individually subjected to an observational compartment next to the training compartment wherein three demonstrators received 1)a daily 30-min presentation of vanilla odors for 3 consecutive days; or 2)3-days of 30-min vanilla odors contingent on the delivery of 15 pseudo-randomly-arranged footshocks (0.5 mA, 2 s in duration per shock). Vanilla odors-induced freezing response (FR) was used to indicate observers’ vicarious learning magnitu

Perception and action in humans and rodents require a well-functioning embodied self. To sustain embodiment, the brain must continuously adapt to the dynamic changes of the animal’s body. Research over the past decades has suggested that embodiment may occur during active or rapid eye movement (REM) sleep. Brief jerky movements or (myoclonic) twitches, mainly described to occur during REM sleep have been proposed as a mechanism through which the brain maps motor output with sensory input, establishing a vital sensorimotor loop essential for embodiment during early development. However, while t