Topic: adult neural stem cells

Due to the complexity of the events in the tissue after the traumatic brain injury, adequate therapeutic protocols still need to be improved. A growing number of data suggests that hyperbaric oxygenation (HBO) can influence the activity of adult neural stem cells (NSCs). The aim of this study was to investigate the effects of sensorimotor cortex ablation (SCA) and HBO on processes of neurogenesis in the subventricular zone (SVZ), rostral migratory stream (RMS) and around the lesion site. The experiments were performed on adult male Wistar rats, ten weeks old. Animals were randomized into two g

Despite the promise of direct neuronal reprogramming to drive transformative research, several challenges hinder its practical application in multiple contexts. Among them, the mechanisms safeguarding cellular identities in adult neurons may obstruct conversion between neuronal lineages and hinder the generation of specific induce neuron (iN) subtypes from non-neuronal cells. This study investigates whether the epigenetic regulator Ring1b, a crucial component of the Polycomb-Repressive-Complex-1 that controls neuronal specification in development, plays a role in the mentioned mechanisms. We f