Cognitive performance is enhanced by aerobic-strength training, and related to physical fitness and reduced platinum levels in testicular germ cell cancer survivors
Platinum-based chemotherapy can accelerate cognitive and metabolic decline in cancer survivors. Physical exercise has a potential to reduce chemotherapy-related toxicity. Our aim was to assess the effects of aerobic-strength training on cognitive functions, physical fitness and metabolism in testicular germ cell tumour (TGCT) survivors, treated with platinum-based chemotherapy. TGCT survivors were enrolled in a 6-month intervention (supervised aerobic-strength training / controls n=20 / 8, age 42.1±7.6 yrs, BMI:27.7±3.8 kg/m², VO2max:29.2±6.7 mlO2/kg/min, 1-20 years post-treatment). Abdominal