Topic: akinesia

The freezing of gait (FOG) is a debilitating symptom of Parkinson’s disease (PD), which is resistant to dopamine replacement and deep brain stimulation (DBS) therapies, thus it is a clinical and scientific challenge. Modern DBS devices can record brain activity from chronically implanted electrodes, and animal models can be used to investigate motor network impairments at different biological scales. The combination of these tools posits a plethora of opportunities to identify gait-related biomarkers to improve gait therapy using closed-loop DBS in patients. Towards this goal, my PhD project a

Aim: The intricate development of Parkinson's disease (PD) has posed a significant challenge in finding effective treatments. In the current study, a diaryl pyrrole compound, 1-(2-chlorophenyl)-2-methyl-5-(4-chlorophenyl)-1H-Pyrrole, was designed, synthesized, and tested for possible motor function improvement in 6-hydroxydopamine (6-OHDA) induced neurotoxicity in a rat model of PD.Method: Parkinsonism was triggered unilaterally by injecting 6-OHDA (12μg/4μl/rat) into the striatum. The compound (1,5,10 and 30 mg/kg) was then given intraperitoneally for 14 consecutive days following the 6-OHDA