Topic: β-amyloid

Aging leads to the accumulation of misfolded proteins, such as β-amyloid and α-synuclein, which are believed to underly the onset of neurodegenerative disorders. Most of the treatments for brain disorders come from pre-clinical evidence in males, although women are more vulnerable than men to Alzheimer’ disease (AD) which is the first cause of age-related dementia. However, the mechanisms underlying these sex-differences are not known.To date, two therapeutic approaches are predominantly used to prevent and/or slow neurodegeneration; they include autophagy pharmacological enhancers and exercis

Development of accurate biomarkers in the Alzheimer’s disease (AD) macaque model remains unattainable, in part because which aspects of macaque aging truly reflect comparable aspects of AD pathophysiology is unclear. To assess neuropathologic evidence underpinning biomarker development in macaques, we quantified ß-amyloid, pTau (AT8), neuroinflammatory marker and p16-expression in aging macaques (n=10) and AD patients (n=5). We assigned AD neuropathologic (ADNP) scores according to consensus guidelines. Further, we examined expression of pT217 and pT181 markers, acetylcholinesterase, tyrosine