Topic: Amyloid Beta 1-42

We aimed to investigate the effect of taurine especially on apoptosis and also inflammatory and oxidative processes in an Alzheimer-like disease model induced by intracerebroventricular(icv) Amyloid Beta 1-42(Aβ1-42) injection.30 Wistar Albino rats were divided into 4 groups: Control(n:7), Taurine(n:7), icv Aβ1-42(n:8), icv Aβ1-42+taurine(n:8). After administration of icv Aβ1-42 to the relevant groups, taurine groups received taurine by oral gavage at 250 mg/kg/day for 32 days. Rats were sacrificed on day 33. Analysis were performed on rat brain tissue. To evaluate the apoptosis bax, bcl-2, cl

Pathologically activated connexin hemichannels can establish a self-propagating inflammasome activation loop that may contribute to Alzheimer’s disease (AD). This study aims to investigate the potential of modulating the inflammasome loop through connexin hemichannel blockade in a mouse model of AD known to display neurodegeneration, neuroinflammation, and memory deficits. One day after intrahippocampal injection of aggregated amyloid beta 1-42 (AB1-42), treatment mice (n=8) were administered a connexin hemichannel blocker, Tonabersat, in a peanut butter pellet for 16 days before tissue collec