Topic: Amyloid beta oligomers

Alzheimer’s disease (AD) early stages are characterized by amyloid beta oligomers (oAβ) toxicity in the hippocampus, leading to its dysfunction. Previously, we characterized a non-transgenic mouse model of early amyloidosis by a single intracerebroventricular (icv.) injection of oAβ1-42, that showed deficient hippocampal-dependent memory and synaptic plasticity impairment in the CA1–CA3 synapse regardless the sex. Social memory impairments have also been described in AD. However, neuronal oscillatory activity in hippocampal CA2 subfield, a region that plays a crucial role in the formation and

RNF10 is a protein with multiple cellular functions. It has been described as a E3-Ubiquitin ligase, with a key quality-control role during the initiation of translation in the early regulatory ribosome ubiquitylation (RQC). In addition, RNF10 plays in neurons a role as a synaptonuclear messenger, involved in the NMDA receptors (NMDAR) signaling cascade. RNF10 binds to the C-terminal region of the GluN2A subunit of the NMDAR and its translocation from the synapse to the nucleus translates synaptic NMDAR activation into gene expression changes. RNF10 is crucial in the physiology of the neurons,