Topic: amyloid-β plaques

Alzheimer’s disease is a progressive age-associated neurodegenerative disease, characterised by the presence of two key neuropathological hallmarks; amyloid-β plaques and neurofibrillary tangles. Understanding how amyloid-β behaves “in vivo” prior to symptomatic onset is an important question that has previously only been inferred by peripheral measurements (CSF, PET). Here we use human brain slice cultures to model aspects of amyloid-β AD pathology, by both assessing how endogenous properties and pathology relate to patient characteristics, and by induced perturbations using pharmacological t

Alzheimer’s disease (AD) is characterized by memory deficits including spatial working memory. The hippocampus (HPC) and the prefrontal cortex (PFC) exhibit a prominent AD pathology and are relevant brain regions for spatial working memory. The HPC and PFC are connected by long-range projections and operate in synergy to consolidate and retrieve memories. Both, excitatory and inhibitory long-range projections between the HPC and the PFC have been poorly characterized under AD-like conditions. In fact, it remains unknown, whether structural and functional connectivity deficits between these bra