Topic: Angiotensin II

Traumatic spinal cord injury (SCI) leads to the immediate activation of the hypothalamus-pituitary-adrenal (HPA) axis. However, its proper function is impaired due to primary and secondary injury to the neural pathways of the sympathetic nervous system innervating the adrenal gland. Disruption of sympathetic innervation can strongly influence the expression of Angiotensin II receptors that are found at all levels of HPA axis. In this study, circulating Angiotensin II levels and the expression of Angiotensin II receptors within HPA axis after compression-induced SCI (40g weight for 15 min) at t

Blood-brain barrier (BBB) disruption and the consequent alteration of solute and ion transport play a pivotal role in the onset and progression of many neurological diseases, including epilepsy. Among the players that have been shown to modulate BBB function, our group recently demonstrated that Kv7 channels, a family of voltage-gated potassium channels, are critical modulators of barrier permeability, both in physiological conditions and experimental models of seizures. Accumulating evidence suggest that the renin-angiotensin system (RAS) is altered during epilepsy and affects BBB permeabilit