Topic: anti-inflammatory effects

Progranulin (PGRN), encoded by the GRN gene, is a potent neurotrophic and anti-inflammatory factor expressed by neurons and microglia. Heterozygous or homozygous loss-of-function mutations in the human GRN gene cause frontotemporal dementia and neuronal ceroid lipofuscinosis, respectively. Previous studies also demonstrated exacerbated consequences in Grn-deficient mice after experimental traumatic brain injury (TBI). However, the relative contribution of neuronal or microglial PGRN in neuroprotective and anti-inflammatory effects is still elusive. Here, we tested the hypothesis that transgeni

Scalp acupuncture (SA) has shown potential as a treatment for acute ischemic stroke. This study investigated the effects and mechanisms of SA in rodent stroke models using systematic review, animal experiments, and analysis of peripheral responses. Subsequent animal studies confirmed the anti-inflammatory effects of SA, showing reduced TNF-α, IL-1β, IL-6 and increased IL-10 in rat stroke brains. SA enhanced neurological outcomes, as measured by the 6-point neuroscore, cylinder test, and grip strength test. Although SA's reduction in stroke infarct area was not statistically significant, it not