Topic: anti-NMDAR encephalitis

Anti-NMDAR encephalitis (NMDARe) is a disorder mediated by antibodies against the GluN1 subunit of NMDAR. Patients develop severe neuropsychiatric symptoms that usually improve with immunotherapy, although very slowly. To better understand the neuro-immunobiology of the disease and how different treatments might work, we aimed to develop an animal model that reproduced most of the symptoms and their protracted clinical course. Eight-week-old female mice (C57BL/6J) were immunized (days 1 and 28) with GluN1356-385 peptide or saline with AddaVax adjuvant and Pertussis Toxin. After developing symp

Autoantibodies (aAb) against N-methyl-D-aspartate receptor (NMDAR) mediate autoimmune Anti-NMDAR encephalitis. This leads to the development of various symptoms, including seizures, memory deficits, cognitive dysfunction, and psychosis. Our current understanding of the pathophysiology remains limited. Particularly the crucial molecular insights of autoantibody recognition and the influence of their binding on the function of NMDARs. To address these knowledge gaps, we characterized three patient-derived monoclonal antibodies in a multi-modal approach, encompassing super-resolution microscopy,