Topic: anxiety-like behaviours

FTY720 (fingolimod), a synthetic sphingosine 1-phosphate (S1P) analogue, is a drug employed for treating relapsing-remitting multiple sclerosis in diverse age groups. With the ability to cross the blood-brain barrier, FTY720 gradually accumulates within lipid-rich areas of the central nervous system (CNS) by integrating into phospholipid membranes. Consequently, FTY720 can enhance cell membrane fluidity, influencing glial cells and neuronal populations involved in behaviour regulation. This study investigated the impact of chronic FTY720 administration (3.3 μg/ml in ad libitum drinking water f

Global cerebral ischemia (GCI) causes extensive neuronal injury and significant behavioural impairments. Although these sequelae can be mitigated by selective activation of estrogen receptors (ERs), their influence on inflammatory processes mediated by microglial activation are not fully understood. This study characterized the impact of selective ER activation on post-ischemic anxiety-like behaviours and microglial activation. 46 adult female Wistar rats were ovariectomized and, starting the following day, received daily subcutaneous injections of propylpyrazole triol (ERα agonist), diarylpro