Topic: anxiety-like phenotype

Parkinson’s disease (PD) is usually thought of as a motor disorder, although non-motor symptoms may precede the motor manifestations and are a key component of the PD. Among these, depression and anxiety are most prevalent symptoms and caused a greater symptomatic burden in women than in men. A dysfunctional serotonin (5-HT) system is generally considered a risk factor for depression. We propose the ventromedial prefrontal cortex (vmPFC)-dorsal raphe nucleus (DR) circuit as the key player underlying depressive/anxious disorders in PD, by virtue of its reciprocal connectivity. Female mice overe

Obesity and excessive consumption of saturated fats represent important predisposing factors to the development of neurodegenerative disorders such as Alzheimer's disease (AD) and its neuropsychiatric comorbidities. Alteration of amyloid β (Aβ) homeostasis is considered the main neuropathological feature of AD and increased levels of the oligomeric forms of this peptide have been associated with increased risk of depressive states. The exposure to obesogenic environment, such as high fat diet (HFD), seems to impair Aβ catabolic function leading to the production of its neurotoxic species. In t