Topic: anxiety-related behaviors

A reduction of food intake – and concurrent loss of body weight – in combination with physical hyperactivity are main symptoms of the eating disorder anorexia nervosa. Continuous loss of fat mass results in hypoleptinemia, which initiates multiple starvation-related adaptive functions. Although leptin administration showed beneficial effects in treatment of symptoms of anorexia nervosa, including anxiety, neuronal mechanisms of possible anxiety-relieving action of leptin are not known.Here, combining calcium imaging and opto- or chemogenetics in freely behaving mice, we investigated functions

The nucleus accumbens (NAc), a brain region implicated in the regulation of anxiety-related behaviors, has been found to be susceptible to blood brain barrier (BBB) permeability in psychopathologies. Additionally, the positive effects of testosterone on BBB function and anxiety related behaviours is still controversial. In this study, exploiting natural phenotypic variation in anxiety-like behaviors in outbred Wistar male rats, we aimed at investigating whether testosterone plays a role in anxiety-related BBB disfunction. We classified animals as high (HA) or low anxious (LA) according to the