Topic: anxiety-related behaviour

LNX1 and LNX2 proteins are closely related PDZ domain-containing E3 ubiquitin ligases expressed in neurons. They can interact with and potentially modulate a numerous synaptic proteins, but the in vivo physiological relevance of most of these interactions remains uncertain. We previously reported that mice lacking both LNX1 and LNX2 in the central nervous system exhibit decreased anxiety-related behaviour. Separately, abnormalities in social learning and sociability were described in a distinct LNX1 knockout mouse line. To extend this work we have examined: (1) anxiety-related behaviour in LNX

High fat diet (HFD) chronic intake induces metabolic syndrome in mice, characterized by a body weight increase and insulin resistance (IR). Furthermore, non-alcoholic fatty liver disease (NAFLD) is strongly linked to metabolic syndrome appearance. Obesity is a risk factor in the development of neurodegenerative diseases, neuropsychiatric disorders and is associated with cognitive decline. DREAM/kchip3/calsenilin (DREAM) is a multifunctional protein that belongs to the neuronal Ca2+ sensor family. Previous studies have demonstrated the relevance of DREAM in nociception and in learning and memor