Topic: anxiolytic effects

Evolution has preserved many molecular pathways, establishing invertebrates as versatile models for exploring the fundamental and universal processes of CNS physiology and pathology. Among them, the pond snail Lymnaea stagnalis serves as an effective model organism for Translational Neuroscience due to its relatively simple CNS and open circulatory system, simplifying the exploration of the complexity of conserved molecular pathways and allowing to investigate how drugs can modulate neuronal functions and behaviors. In this study, we discovered that, despite never encountering natural predator

Green light has been shown to relieve pain and anxiety, but the underlying neural mechanisms remain unknown. Here, we show that low-intensity (200 lux) green light treatment exerts antinociceptive and anxiolytic effects through a neural circuit from the visual cortex projecting to the anterior cingulate cortex (ACC) in mice. Specifically, viral tracing, in vivo two-photon calcium imaging, and fiber photometry recordings show that green light activated glutamatergic projections from the medial part of the secondary visual cortex (V2MGlu) to GABAergic neurons in the ACC, which drives inhibition

Subplate neurons are among the earliest generated neurons in the cerebral cortex that orchestrate the development of the intra and extracortical connections. A large proportion of these neurons undergoes cell death throughout postnatal development. The remaining cells form the thin and compact cortical layer 6b (L6b) in murine cortex. The functional aspects of L6b have received little attention compared to the other layers. Recent studies have argued that the extensive intracortical connections and cortico-thalamic-cortical loops of L6b neurons might enable sensory processing to extract salien

The ventral hippocampus has emerged as a central hub for the orchestration of negative effects. We employed wireless amperometric O2 measurements in freely moving rats as a surrogate readout for changes in neuronal activity with translational value for fMRI studies in humans. From the Research Domain Criteria (RDoC) matrix, here, mainly one branch, namely the negative valence system is addressed using a modified Elevated Plus-Maze, male Wistar rats are tested under controllable (modified Elevated T-Maze, mETM with free exploration of one open and two closed arms) and uncontrollable (Open Arm C

It is commonly recognized that amygdala plays a critical role in the modulation of anxiety. Furthermore, alpha-2 adrenergic receptor activity has been suggested to be involved in anxiety modulation. The aim of this study was to ascertain whether the central amygdaloid nucleus, which represents the main anxiogenic output of amygdala is involved in such adrenergic actions. Elevated Plus-Maze and Shock-Probe-Burying paradigms were used to study the effects of sterotaxically-infused clonidine, a specific alpha 2 adrenergic agonist on anxiety. DSP-4, a toxin specifically destroying locus coeruleus