The ketogenic diet suppresses appetite altering orexigenic and anorexigenic pathways in hypothalamus of diet-induced obese and lean mice
Mateusz Grabowski, Konstancja Grabowska, Natalia Pondel, Marta Nowacka-Chmielewska, Daniela Liśkiewicz, Jarosław Barski · FENS Forum 2024
Obesity, a widespread health issue, accompanied by various metabolism-related disabilities, has emerged as a significant public health challenge. Primary intervention for obesity involves lifestyle changes, including dietary treatments. The ketogenic diet (KD) is increasingly recognized as a potential remedy for obesity, with its efficacy attributed to appetite suppression in the hypothalamus.The study aimed to evaluate how the metabolic changes in hypothalamus, associated with obesity affect the mechanisms responsible for appetite regulation during KD treatment.Adult male mice were subjected
ePoster · Neuroscience