Application specific integrated circuit

Expanding use of large-scale neural recordings has led to paradigm shifts in how neural computation is understood [1]. Technologies used for collecting these datasets face fundamental limitations ranging from power dissipation, penetration depth, and resolution [2] while facing additional practical challenges related to sensor integration with the subject or patient. While the ultimate goal of simultaneously recording from every neuron in the brain is far out of reach, more modest advancements still need to be made to ensure the proper neural coverage is achieved to construct a sufficient app

Ultraflexible probes offer a revolutionary approach to stable neural recording and stimulation by creating a glial scar-free neuronal interface utilizing biocompatible materials in compact cross-sectional areas. However, these probes don’t have an equivalent number of electrodes within the same invasive footprint as rigid probes have. This limitation stems from photolithography, which is used for fabricating ultraflexible probes, is not capable of yielding a similar high electrode density. Here, to record more neurons per implantation, we introduce a novel fabrication technique utilizing elect