Seminar · Neuroscience
Evidence for the role of glymphatic dysfunction in the development of Alzheimer’s disease
Jeffrey Iliff · VA Puget Sound Health Care System, University of Washignton, Seattle, WA, USA
Mon, Oct 25, 2021 · 15:00 UTC
Glymphatic perivascular exchange is supported by the astroglial water channel aquaporin-4 (AQP4), which localizes to perivascular astrocytic endfeet surrounding the cerebral vasculature. In aging mice, impairment of glymphatic function is associated with reduced perivascular AQP4 localization, yet whether these changes contribute to the development of neurodegenerative disease, such as Alzheimer’s disease (AD), remains unknown. Using post mortem human tissue, we evaluated perivascular AQP4 localization in the frontal cortical gray matter, white matter, and hippocampus of cognitively normal sub