ePoster · Molecular Neuroscience
Are mitochondria a missing link between arginase 2 loss and Huntington’s disease pathogenesis?
Martyna Podgajna, Magdalena Gewartowska, Aleksandra Kaczynska, Aleksandra Owczarek, Karolina Szczepanowska, Michal Wegrzynowicz · FENS Forum 2024
Arginase 2 (Arg2), an arginine-metabolizing, mitochondrial enzyme, has been recently found to be enriched in the striatum, and progressive loss of Arg2 has been proposed as a potential factor contributing to the pathogenesis of Huntington’s disease (HD), a disorder primarily involving this region of the brain. Although direct metabolic role of Arg2 is well established, the importance of this enzyme for striatal function and dysfunction is not known. The purpose of this work was to identify cellular pathways potentially controlled by Arg2 in the striatum. In our experiments, we have used wild-t