Topic: ASIC1a

Aim: Acid-sensing ion channels 1a (ASIC1a) are widely distributed in the mammalian nervous system and in particular brain areas including the hippocampus. ASIC1a is highly permeable to Ca2+ and its activation has a crucial importance in numerous physiological and pathological processes, including synaptic plasticity, learning and memory. To further understand the role of ASIC1a channels in the synaptic alterations induced by Aβ, we carried out electrophysiological experiments investigating the effects of a ASIC1a-blocking monoclonal antibody ASC06-IgG on hippocampal long-term potentiation (LTP

Acid-sensing ion channel 1 (ASIC1) is a trimeric ion channel, opened by a fast drop of extracellular pH. ASIC1 is highly abundant in the CNS and present at the postsynapse. In slice recordings of the lateral amygdala, it was shown, that ASIC1 can be activated by protons co-released by transmitter exocytosis, thus contributing to synaptic transmission. Intriguingly, ASIC1-dependent current was small compared to currents of GABA or Glutamate receptors, however, ASIC1 was reported to have a significant impact on various physiological and pathophysiological processes e.g. fear related behavior, lo