Topic: atropine

Organophosphate (OP) nerve agent (NA) like VX are irreversible acetylcholinesterase (AChE) inhibitors. Acute NA exposure leads to a cholinergic syndrome, due to acetylcholine accumulation in synapses, manifested by fasciculation, tremors, muscle paralysis and a respiratory distress leading to death. Antidote treatment includes a muscarinic cholinergic receptor antagonist (atropine) and an oxime able to reactivate OP-inhibited AChE. In central nervous system, oximes action is limited due to their weak ability to cross the blood brain barrier (BBB). The goal of this study was to test therapeutic

The involvement of the Enteric Nervous System (ENS) in digestive and neurological disorders is widely recognized and constitutes a novel target for diagnostic biomarkers and therapies. For example, Parkinson’s disease patients are now stratified according to gut-first or brain-first patterns that diverge in symptom progression. However, large-scale characterization of this neuronal network is often limited to local sampling that cannot reflect network dynamics. We present a new method for minimally invasive in-vivo intraluminal investigation of electrophysiological activity from the entire dis

Neural activity and bodily functions are inherently rhythmic and related to each other. Hippocampal sharp-wave ripples (SPW-Rs) and dentate spikes (DSs) supporting memory consolidation are most abundant during sleep, especially during non-rapid-eye-movement (NREM) sleep. They also seem to aggregate to a certain phase of the breathing cycle during natural sleep in mice. Here, we aimed to study if the interhemispheric synchrony of SPW-Rs and DSs is affected by neural and bodily state. We recorded dorsal hippocampal local-field potentials and respiration for several hours under urethane anesthesi