Topic: audiogenic seizures

An exquisite characteristic of the auditory system is its ability to sense a large range of sound intensities from whispers to loud alarm sounds, covering 6 orders of magnitude in acoustic pressure. Deficits of sound intensity processing may lead to hearing loss and/or major auditory perception distortions like tinnitus, the perception of phantom sounds, or hyperacusis, a reduced tolerance for moderate sound levels. Audiogenic seizures, reflex seizures induced by loud sounds, are a common feature of many mouse models for central nervous system disorders and may be seen as a model of auditory h

Sudden unexpected death in epilepsy (SUDEP) is a dramatic outcome for epileptic patients, with a prevalence of 1 per 1000. Stiripentol (STP, Diacomit©) is an antiseizure medication indicated for Dravet syndrome, a rare developmental and epileptic encephalopathy with high mortality rate (15 per 1000), in which SUDEP accounts for about 2/3. Here, we evaluate the effects of STP on seizures and death using audiogenic seizure in a preclinical model of SUDEP.In the DBA/2 SUDEP model, audiogenic seizures were induced, and different concentrations of STP were tested at various timings between administ