Topic: auditory detection task

Perception balances what we sense with what we expect. To maintain accuracy, our brains must continuously update sensory expectations when predictions don't match reality. To investigate this, we trained mice on an auditory detection task with hidden switches in stimulus probability across trials. Mice dynamically adjusted their decision thresholds, tracking these changing sound probabilities. We monitored dopamine in the tail of the striatum (TS), a region at the interface of sensory processing and action selection that receives direct auditory cortex inputs. Given mesolimbic dopamine's estab

Animals adapt their behaviour to novel situations, quickly learning to respond appropriately to external stimuli. While different brain areas are thought to make distinct contributions to goal-directed behaviour, it remains unclear how the brain as a network of areas enables goal-directed learning. Here, we developed a behavioural paradigm that allows us to probe rapid reward-based sensorimotor learning in mice, overcoming the limitations of longitudinal recordings. Mice are first pretrained on an auditory detection task and, once expert, are transferred to a whisker-based tactile detection ta