Topic: auditory discrimination

Cochlear Implants (CI) have been successful at restoring meaningful hearing perception in many deaf patients. However, rehabilitation for patients with damaged auditory nerves are scarce: the only alternative is the Auditory Brainstem Implant (ABI), which presents poor clinical outcomes and difficult surgical approach.Here, we propose to target the auditory cortex directly, using a soft auditory cortex implant, for hearing restoration. By leveraging microfabrication techniques, we developed soft Electrocorticography (ECoG) arrays that would conform the curvilinear surface of the cortex, suppor

Over the last decades, a large number of studies have described the robustness of auditory cortex responses when target stimuli are presented in situations of acoustic degradations (Nagarajan et al.2002, Mesgarani et al. 2014, Town et al, 2018). In few experiments, comparisons have been made with the resistance to noise observed from subcortical neurons recordings (Schneider and Woolley.2013, Rabinowitz et al .2013). Moreover, several studies claimed that the behavioural discrimination performance correlates with the auditory cortex neuronal responses. In previous experiments performed in anae

The Default Mode Network (DMN) is a task-negative network composed of mainly cortical areas with elevated activity during ‘autopilot’ states and decreased activity during goal-directed behavior. Work from our laboratory implicates a basal forebrain node, the ventral pallidum (VP), in the regulation of DMN, suggesting that it dramatically impacts transitions between internally and externally guided behaviors. While VP activation has been shown to positively correlate with DMN upregulation and vice versa, it remains unclear which efferent VP neural pathways mediate these effects. We examine this