An innovative approach for conducting 3D electrophysiological recordings within intact brain organoids
Julio Alvarez, Sara Mirsadeghi, Ali Hosseini, Sven Schoenecker, Peter Jones, Michele Giugliano, Jenny Hsieh · FENS Forum 2024
Brain organoid technology is a pivotal tool for exploring human brain physiology and diseases. Despite its potential, current readout capabilities constrain brain organoid electrophysiological research. Classical microelectrode arrays (MEA) fall short in capturing data from intact organoids, which may flatten in the 2D-MEA surface, jeopardizing physiological responses and data validity. To overcome this, we pioneered a mesh MEA, preventing morphological deformations, fostering 3D growth, and facilitating electrical activity recording within intact organoids over an extended period. Electrophys
ePoster · Neuroscience