Topic: axonal damage

Peripheral neuropathy is characterized by damage to the peripheral nerves, leading to symptoms such as numbness, tingling, and pain in the extremities. While peripheral neuropathy can be caused by several factors, a common cause is toxicity from chemotherapeutic drugs.We studied chemotherapy-induced peripheral neuropathy (CIPN) using the OrganoPlate, a microfluidic cell culture platform that allows culture of 40 chips in parallel. Human iPSC-derived peripheral neurons were embedded in extracellular matrix gel and seeded into the OrganoPlate, after which they extended their axons into an adjace

Spinal cord injury is associated with axonal damage and degeneration, leading to the dysfunction of neuronal networks and hence, severe impairment of neurological function. Injured neurons response depends both on extracellular cues (mainly non-permissive, such as myelin debris, extracellular matrix protein such as CSPG, glial and fibrotic scar, inflammatory cues, …) and their intrinsic capacity. How microtubule-associated protein (MAP) contribute to this response is the objective of the present work. MAP6 is the first neuronal microtubule (MT) inner protein discovered and preliminary results