Topic: axonal growth

Early experiments studying the effects of lesions of the Hippocampus have reported that recent memories are often unavailable to be retrieved, while old memories are successfully reminded. These observations have led to state the theory of Systems Consolidation. This is the process by which the fast-learning Hippocampus replays the encoded memory during sleep and thus consolidates the corresponding memory in the Neocortex [1]. Formation of memory would take longer in the Neocortex because of its much larger spatial scale compared to the Hippocampus, and thus requires axonal growth and synaptog

Our study investigates the potential synergistic effect of regenerative therapy combining electrical stimulation with application of anti-inflammatory drug atorvastatin (ATR) following spinal cord injury (SCI). Using an isoflurane anesthesia, we induced SCI at the T9 segment with a compression device for 15 minutes under a 40g weight. An oscillating field stimulator (OFS) implanted subcutaneously delivered a weak electric current (50 µA), alternating polarity every 15 minutes for 6 weeks to encourage axonal growth from the lesion site. Wistar albino female rats were randomly divided to four gr