ePoster · Molecular Neuroscience
How the presynapse shapes its molecular composition in an energetically optimal manner
Nestor Timonidis, Cornelius Bergmann, Tatjana Tchumatchenko · Bernstein Conference 2024
Understanding how neurons regulate their protein composition to refine synaptic connections across millimeters of space provides critical insights into the mechanisms of synaptic plasticity. The discovery of local protein synthesis in subcellular compartments has shown how neuronal activity can locally meet the metabolic demands of synaptic plasticity$^{1,2}$. Despite the experimental challenges posed by the long and complex branches of axons, the presence of mRNA and local protein synthesis in presynaptic boutons has been clearly demonstrated$^{3,5}$. In this study, we developed an in silico