Topic: axonal regeneration

Traumatic brain injury (TBI) is one of the leading causes for death or disability involving an initial mechanical damage that leads to the destruction of the brain matter and adjacent vasculature, producing a lesion cavity. The treatment options are limited to stabilizing the patients and treating secondary symptoms. Those secondary injuries appear in a time-shifted manner and include axonal injury leading to neuronal death, a process not fully understood yet. For several central nervous system (CNS) injury models including spinal cord injury, it was already shown that the growth factor-activa

Spinal cord injury (SCI) initiates a series of sensory, motor, and autonomic dysfunctions induced by the disconnection of the brain-spinal cord axis. In this context, Piezo4Spine PathFinder project (GA 101098597) aims to develop a multifactorial therapy for SCI using biocompatible and biodegradable materials containing nanoparticles loaded with therapeutic agents that will be controlled delivered at the injury site. With this strategy, our purpose is to promote axonal regeneration and connectivity of the brain-spinal cord axis to recover sensory and motor functions. We have designed and analys

Spinal cord injury represents a complex and serious medical condition characterized by damage to the spinal cord, causing profound functional impairment. The consequences of such an injury may include paralysis, loss of sensation, and disruptions in vital bodily functions, such as bladder and bowel control. The renin-angiotensin system, predominantly acting through the AT1 receptor, regulates blood pressure and hydro-electrolytic balance. However, the AT2 receptor (AT2R) also plays a crucial role, especially in processes related to neuroregeneration. In the present study, the AT2R was stimulat

Spinal cord injury is associated with axonal damage and degeneration, leading to the dysfunction of neuronal networks and hence, severe impairment of neurological function. Injured neurons response depends both on extracellular cues (mainly non-permissive, such as myelin debris, extracellular matrix protein such as CSPG, glial and fibrotic scar, inflammatory cues, …) and their intrinsic capacity. How microtubule-associated protein (MAP) contribute to this response is the objective of the present work. MAP6 is the first neuronal microtubule (MT) inner protein discovered and preliminary results

Restoring the regenerative capacity of adult neurons after spinal cord injury has been an important challenge of the past decades. Unlike the peripheral branch of the nervous system, CNS axons fail to regenerate following injury. This inability has a two-fold origin, a neuron-extrinsic and -intrinsic one. The former has been well described in literature and is related to the inhibitory effect of the CNS environment on outgrowth of adult neurites. The latter has been attributed to the cellular makeup of adult neurons which is primed toward synaptic maturity and functionality, as opposed to rege