ePoster · Neuroscience
The role of TCF7L2 transcription factor in the function of thalamocortical circuits
Katarzyna Hryniewiecka, Magdalena Majkowska, Ewa Kublik, Joanna Urban-Ciećko, Marta Wiśniewska · FENS Forum 2024
TCF7L2 is a high-confidence risk gene for neurodevelopmental disorders (NDs), but its role in their pathogenesis is unknown. It is highly expressed in the thalamus - candidate structure for NDs pathogenesis - regulating its electrophysiological maturation. To understand the role of thalamus-expressed Tcf7l2 in signal processing in thalamocortical circuits, we investigated consequences of its deficiency in the somatosensory circuit: first- and higher-order thalamic nuclei (VPM and POM) and the barrel cortex.Tcf7l2 postnatal thalamic knockout mice were used to assess signal gating mechanism in v