Topic: basal ganglia circuits

Midbrain dopamine (DA) neurons send teaching signals, reward prediction errors (RPEs), to all regions of the striatum [1]. However, these signals converge with regionally segregated inputs from all levels of the cortical hierarchy [2] that vary in degree of abstraction and temporal extendedness [3]. Recent work highlights how regionally diverse DA RPEs might update parallel estimates of future reward as informed by region-specific inputs[4, 5], yet the behavioral implications of such parallel processing are poorly understood. We used photometry to measure DA release across the striatum in mice