Topic: BAX

Programmed cell death (PCD) is essential for regulating cell homeostasis in the developing brain. Cell populations that undergo massive PCD in the cortex include the first wave of oligodendrocyte precursor cells (firstOPCs) and most of GABAergic interneurons, which die postnatally within the same period. Furthermore, firstOPCs and most interneurons share common embryonic origins. Here we investigated how PCD of both firstOPCs and their lineage-related interneurons impact behavior and cortical networks. We used behavioral assays, patch-clamp recordings and immunostainings in two mouse models in

Dementia is a syndrome characterized by the progressive loss of cognitive functions, predominantly affecting older individuals. It is often accompanied by behavioral and psychological symptoms, significantly impacting dementia prognosis and treatment. Alzheimer's disease (AD) is the most common form of dementia, primarily affecting neurons in the cortex and hippocampus. The main pathological features of AD include extracellular accumulations of amyloid beta peptides in amyloid plaques and intracellular accumulations of hyperphosphorylated tau protein in neurofibrillary tangles. Since there is