ePoster · Computational Neuroscience
Modulation of Spike-timing-dependent Plasticity via the Interaction of Astrocyte-regulated D-serine with NMDA Receptors
Lorenzo Squadrani, Pietro Verzelli, Janko Petkovic, Tatjana Tchumatchenko · Bernstein Conference 2024
Astrocytes play a crucial role in regulating synaptic strength and orchestrating synaptic plasticity, which is fundamental for learning and memory. However, the specific mechanisms by which astrocytes and their neuroactive transmitters, like D-serine, control these processes remain largely unexplored. D-serine, a co-agonist for the NMDA receptor, has garnered increasing interest as a potential regulatory molecule in synaptic plasticity. Given its activity-dependent release mediated by astrocytes, D-serine is a key player in balancing long-term synaptic depression (LTD) and potentiation (LTP) d