Topic: Beclin-1

Diabetes is a common metabolic disease whose hyperglycemic state can induce various complications, including central nervous system complications. There is evidence which suggests that oxidative stress has a key role in the pathogenesis of diabetes and its complications. Autophagy is one of the main routes to eliminate damaged components in cells in response to oxidative stress. However, excessive autophagy causes a distinct type of cell death involved in the pathogenesis of multiple diseases, such as diabetes. This study aimed to investigate the effect of melatonin on the autophagy in the pre

Spinal cord injury (SCI) results from direct damage to the spinal cord, devastating patients’ quality of life and emotional and economic stability. Unfortunately, fully effective therapeutic strategies have yet to be developed to treat this disease, affecting millions worldwide. Apoptosis and autophagy are critical cell death signaling pathways after SCI that should be targeted for early therapeutic interventions to mitigate their adverse effects and promote functional recovery. Tibolone (TIB) is a selective tissue estrogen activity regulator (STEAR) with neuroprotective properties demonstrate