Topic: behavioral changes

Aims: Survivors of cerebral malaria (CM) might develop lifelong sequelae such as cognitive deficits, altered behaviour or epilepsy. Animal models are needed to understand the underlying pathophysiology and to develop preventive or ameliorating therapies. Therefore, in this study we aimed to establish a mouse model reflecting consequences of CM. Methods: To ensure survival, C57BL/6 mice infected with P. berghei ANKA (PbANKA) were closely monitored for parasitaemia and clinical signs of CM, and rescued by artesunate treatment. Following electrode implantation, repetitive EEG-video monitoring was

This study aims to explore the impact of social isolation on memory, learning and behavioral changes in middle aged Sprague Dawley (SD) and Wistar Albino (WIS) rat strains and to investigate cortical trace element levels, seeking potential correlations between these levels and the observed behavioral responses to social isolation. Four groups of 14-month-old male rats established: control and isolated SDs and WIS rats (CONT-SD, ISO-SD, CONT-WIS, ISO-WIS). Morris Water Maze (MWM) and Porsolt Forced Swimming (PFS) tests were conducted for behavioral assessment. Following behavioral tests, rats w