Topic: behavioral inflexibility

Obsessive-compulsive disorder (OCD) is characterized by persistence and inflexibility in behavior and in thought processes. The putative (in)flexibility in neuronal activation patterns that underlies these pathological behavioral and cognitive symptoms is largely unexplored. We used electrophysiological tetrode techniques to study neuronal activity in anterior cingulate cortex (ACC) and hippocampus in a rat model of OCD based on repeated exposures to D2 and D3 receptor agonist quinpirole. We aimed to characterize spatial and temporal stability in neuronal activation and its relationship to obs

Neurofibromatosis type 1 (NF1) is a monogenic but highly multisymptomatic disorder that affects 1:2500 individuals and results from mutations in the Nf1 tumor suppressor gene. Nf1 encodes Neurofibromin (Nf1), a large multifunctional protein, preferentially expressed in the central and peripheral nervous system, crucial for regulating multiple signaling pathways. Although typically considered a tumor predisposition syndrome, NF1 is also associated with broad cognitive and behavioral presentations, including impaired learning, attention deficit hyperactivity disorder, autism spectrum disorder, s