Topic: behavioral transitions

Locomotor behaviors are composed of ordered transitions between motor states required to produce a functional outcome. However, the circuit mechanisms by which the brain generates a sequential ordering of motor actions for constructive behavioral output, particularly in freely-behaving animals, is largely unknown. With 302 neurons within a well-defined connectome and a library of genetic tools, complex yet discernible behaviors, and recent advances in brain-wide imaging, the nematode Caenorhabditis elegans offers a unique opportunity to study how the brain generates behavior. To better underst

The ability to switch between different behaviors is essential to all animals’ survival. Behavior selection is influenced by sensory inputs, internal states, and memory, suggesting that neural mechanisms across the brain coordinate these decisions. While investigating the neural basis of behavioral switching requires whole-brain imaging, current methods face challenges in behaving animals. We employed functional ultrasound imaging (fUS) to record large-scale neural activity in head-fixed mice while simultaneously tracking their behavior. Our aim was to identify brain regions that predict trans

The ability to switch between different behaviors is essential to all animals’ survival. The selection of a behavior is guided by multiple factors, such as sensory inputs, internal states, and memory, which suggests that regions across the brain are involved in the decision to switch between them. While whole-brain information is necessary to investigate the neural basis of behavioral switching, brain-wide imaging in behaving mice has proved challenging so far. We employed functional Ultrasound imaging (fUS) to record large-scale neural dynamics in head-fixed mice while simultaneously tracking