Topic: bilateral integration

During behavior, cortical neurons are continuously integrating task-relevant information from the opposite hemisphere. While the importance of bilateral integration to behavior may appear obvious, its underlying neural mechanisms are almost entirely unknown. Naïve models of processing often assume that bilateral integration only occurs at higher cortical levels, despite an abundance of interhemispheric (IH) circuits in the primary sensory cortices. However, the basic circuit logic by which the corpus callosum operates remains poorly understood. To reveal the logic of bilateral integration and

Bilateral sensory information is indispensable for navigating the world. In most mammals, signals sensed by either side of the midline will ultimately reach the cortex where they will be integrated for perception and appropriate action selection. Even though information transferred across the hemispheres is routed through the corpus callosum, how and which microcircuits are key in integrating it across development is not well understood. Here we identify an essential role for layer 1 NDNF+ inhibitory cells of mice in controlling the bilaterally evoked whisker stimulation in layer (L)4 before,