Topic: biotinylated dextran amine

Neuromotor systems can functionally recover after local damage, but changes in the underlying cortical network remain unclear. In a nonhuman primate model of primary motor cortex (M1) lesions and motor recovery, we previously reported reorganization of subcortical output projections from the ipsilesional ventral premotor cortex (ip-PMv) to the cerebellum. In this study, we investigated the rewiring of cortico-cortical connections between the ip-PMv and parietal cortex using the same model. We injected biotinylated dextran amine (BDA) into the ip-PMv and compared the BDA labeling in the areas a

Acquired brain injuries (ABIs), such as stroke and traumatic brain injury (TBI), represent global health challenges, stroke ranking as the third leading combined cause of death and disability, and TBI contributing to over 7 million disability-adjusted life years. Functional recovery in ABIs is influenced by age, older individuals showing poorer recovery. Axonal plasticity, a form of structural neuroplasticity, holds promise for understanding and promoting recovery. Injuries were carried out in 14-month-old male Wistar rats. Focal stroke was induced by unilateral intracerebral administration of

The giant synaptic terminals play an important role transmitting information with exquisite precision and speed. The thalamus, an important center for the integration and relay of sensory information, is the brain region innervated by more giant terminals. These giant terminals act like drivers, delivering primary sensory information from the somatosensory, visual and auditory pathways. In the auditory thalamus, the drivers arise from the inferior colliculus. Surprisingly, we have observed a population of giant synaptic terminals in the auditory thalamus arising from the medial superior olive

The ventral nucleus of the trapezoid body (VNTB) is a major inhibitory hub in the descending auditory system. It receives descending projections from the auditory cortex, the inferior colliculus, and the nuclei of the lateral lemniscus. In turn, the VNTB innervates the contralateral lateral superior olive, the cochlear nuclei (CN) on both sides, and the outer hair cells within the cochlea. Its GABAergic, glycinergic and cholinergic neurons propagate the signals from higher centers to the first stages of the auditory brainstem.We injected the bidirectional tracer biotinylated dextran amine (BDA