Topic: blood-spinal cord barrier

Astronauts endure repetitive episodes of hypergravity (HG) during takeoff and landing of spaceflights, and also in space due to microgravity. We have recently shown subtle BBB breakdown in a mouse model of centrifugation-induced HG (Dubayle et al., 2023); here we have evaluated if the blood-spinal cord barrier (BSCB) was also damaged in this model.Eight-week-old C57Bl/6J male mice were subjected to HG in a centrifuge at 2g for 24h, while control mice stayed in normogravity (N=9/group). Mice were sacrificed after centrifugation, and thoracic spinal cords collected for immunohistochemistry. For

Spinal cord injury (SCI) in mammals leads to a series of cellular and molecular changes affecting self-repair. The breakdown of the blood-spinal cord barrier allows immune cells infiltration secreting various cytokines that, together with neural cells particularly activated microglia, will spread inflammation and aggravate the neurological deficits. Infiltrated immune cells include neutrophils, monocyte-derived macrophages, and T-cells. Most of preclinical studies evaluated this response in two SCI models: contusion (CT) and transection (TS); having distinct mechanical action modes on spinal c