Blue Brain Project

…the neural activity in different brain areas, the interaction between the ultrasonic source and the neuronal tissue is still not fully understood. Several underlying mechanisms have already been proposed to partially explain the interaction between ultrasound and neurons, including mechanosensitivity, flexoelectricity, membrane displacement, and thermodynamic effects. Unders

The Blue Brain Project endeavors to reconstruct and simulate the rodent brain at various scales: from single-neuron gene expression profiles and membrane permeabilities to large-scale neuronal circuits. One important aspect is the biologically accurate morphological structure of neurons, as morphology constrains the connectivity and impacts the functionality of brain networks. Biologically realistic dendrites within brain regions could be successfully synthesized using topological neuron synthesis (TNS), but inter-regional connectivity remains largely an open question which we address in this