Topic: Braak staging

Tauopathy is a hallmark of a broad category of neurodegenerative conditions and Traumatic Brain Injury (TBI). Progression of tau pathology may lead to impaired cognitive conditions leading to dementia. However, previous studies have reported cognitively healthy patients with cortical tau pathologies. The mechanism for this cognitive protection in a tauopathy environment is being investigated by various groups. Astrocytes are essential for physiological homeostasis of brain and reactive astrogliosis is an associated pathology in neuroinflammation associated with TBI. The correlation between lev

The neuroprotective BDNF/TrkB-FL system is compromised in Alzheimer’s disease (AD). Amyloid-beta triggers calpain-mediated TrkB-FL receptor cleavage, leading to TrkB-ICD formation, a novel intracellular toxic fragment. Biological fluids are used to pinpoint potential disease biomarkers and extracellular vesicles (EVs) are cell-specific carriers of promising pathological biomarkers. Thus, this work aimed to investigate the presence of TrkB-ICD in AD human samples and EVs. Protein and RNA was extracted from human AD post-mortem brain samples classified according to the Braak staging (stages 0-II