Brain disorders

The 2027 McKnight Neurobiology of Brain Disorders Award supports research connecting fundamental neuroscience to brain injury or disease, including mechanisms relevant to diagnosis, prevention and treatment. Awards provide USD 100,000 annually for three years, beginning July 2027. Indirect costs and PI/co-PI salary each have a separate 10% total-award cap. Applicants must be independent investigators at US nonprofit research institutions with at least three years in tenured or tenure-track faculty roles. All co-PIs must qualify. Applications close on 15 October 2026 at 17:00 US Central time.

…and progress toward treatments for brain disorders.

…in vivo and are linked to different brain disorders. However, the underlying mechanisms remain largely unknown.We conducted reciprocal immunoprecipitation experiments to explore the underlying mechanisms using CYFIP1-2×Myc and CYFIP2-3×Flag knock-in mice. The results revealed that CYFIP1 and CYFIP2 are not significantly co-immunoprecipitated with each

Available treatments for brain disorders are commonly pharmacological in nature. Yet, the efficacy and the risk/benefit ratio of brain therapeutics -when they exist- are often dampened by the selectivity of the blood-brain barrier and off-target actions of the molecules, at the periphery as well as in the brain. To improve the efficacy of therapeutic molecules for the brain, their loading in polymersomes (synthetic polymer vesicles) represents a promising strategy due to their high stability, versatility and ability to transport drugs with high efficiency. However, encapsulation does not allow

…proper information processing in the brain. Many brain disorders, especially neurodevelopental disorders, are rooted in a specific disturbance of this coordination. In my research group we use a combination of two-photon microscopy and electrophisiology to examine how inhibitory synapses are fromed and how this formation is coordinated with nearby excitatroy synapses.

…as well as cardiovascular disease and brain disorders. The unprecedented interest in developing theranostic radiopharmaceuticals is mainly due to the recent clinical successes of radiometal-based products including: • 177LuDOTA-TATE (trade name Lutathera, FDA approved in 2018), a peptide-based tracer that is used for treating metastatic neuroendocrine tumours • Ga 68 PSMA-11 (FDA approved in 2020), a positron emission tomography agent for imaging

In this lecture, Dr Stevens will discuss recent work that implicates brain immune cells, called microglia, in sculpting of synaptic connections during development and their relevance to autism, schizophrenia and other brain disorders. Her recent work revealed a key role for microglia and a group of immune related molecules called complement in normal developmental synaptic pruning, a normal process required to establish precise brain wiring. Emerging evidence suggests aberrant regulation of this pruning pathway may contribute to synaptic and cognitive dysfunction in a host of brain disorders,

…elements in the pathobiology of many brain disorders. Microglia are the principal immune cells of the brain. The consensus today is that once activated microglia/macrophages can acquire a wide repertoire of pro

…variants to be associated with complex brain disorders. While this really represents a big step forward in understanding the genetic etiology of brain disorders, the functional interpretation of these variants remains challenging. We aim to help with the functional characterization of variants through transcriptomic data analysis. For instance, we rely on brain transcriptome atlases, such as Allen Brain Atlases, to infer functional relations between genes. One example of this is the identification of signaling mechanisms o

The European University for Brain and Technology, NeurotechEU, is opening its doors on the 16th of December. From health & healthcare to learning & education, Neuroscience has a key role in addressing some of the most pressing challenges that we face in Europe today. Whether the challenge is the translation of fundamental research to advance the state of the art in prevention, diagnosis or treatment of brain disorders or explaining the complex interactions between the brain, individuals and their environments to design novel practices in cities, schools, hospitals, or companies, brain resea