Topic: Brain organization

It is increasingly recognized that epilepsy affects human brain organization across multiple scales, ranging from cellular alterations in specific regions towards macroscale network imbalances. My talk will overview an emerging paradigm that integrates cellular, neuroimaging, and network modelling approaches to faithful characterize the extent of structural and functional alterations in the common epilepsies. I will also discuss how multiscale framework can help to derive clinically useful biomarkers of dysfunction, and how these methods may guide surgical planning and prognostics.

Von Economo stated that an "Ideal Cortical Map" would look very different to a parcellation. He suggested that an Ideal Cortical Map would involve the superimposition of many different cortical maps, with changes in each map shown at every single point. In line with this idea, I will discuss our recent research on identifying principal dimensions of cortical differentiation. In particular, I will highlight large-scale patterns of cytoarchitectural differentiation that can be observed using post mortem histology or in vivo microstructure-sensitive MRI. I aim to show how this approach provides a