Topic: brain regeneration

Every three seconds, someone suffers a stroke, a major contributor to global mortality and disability. Stroke survivors often face limited treatment options and significant disabilities. Stem cell therapy holds promise for brain regeneration and functional recovery, yet it's hindered by poor graft survival post-transplantation due to the hostile stroke environment. Our goal is to enhance graft survival and regenerative potential through cell acclimatization using sublethal hypoxic preconditioning or functionalized, compressible cryogel microcarriers. A protocol for obtaining injectable cryogel

Despite the axolotl’s exceptional ability to regenerate complex tissues, little research has focused on this phenomenon in the brain. We aim to understand whether a morphological repair observed during axolotl brain regeneration is accompanied by a functional restoration of neuronal circuits. To do so, we are establishing state-of-the-art neuroscience tools in our model system, namely GCaMP imaging of neuronal activity, behavioral assays and optogenetic stimulation. Using these methods, we will investigate the visuomotor circuit of the axolotl in intact, injured and regenerating conditions.Rec