ePoster · Computational Neuroscience
Graph models of brain state in deep anaesthesia reveal sink state dynamics of reduced spatiotemporal complexity and integration
James Wilsenach, Charlotte M. Deane, Gesine Reinert, Katie Warnaby · FENS Forum 2024
Deep anaesthetisation is an important surgical and explorative tool in the study of consciousness. Much work has been done to connect the deeply anaesthetised condition with decreased functional complexity. However, anaesthesia-induced unconsciousness is also a dynamic condition in which functional activity and complexity may fluctuate, being perturbed by internal or external (e.g. noxious) stimuli. We use fMRI data from a cohort undergoing ultra-slow propofol induction and a dynamic graph modelling framework which characterises changes in functional activity and connectivity as changes in bra