Brain-wide imaging

Sleep’s ubiquitous presence across the animal kingdom underscores its crucial role in an organism’s cognitive, emotional, and physiological function. In mammals, sleep is subdivided into two distinct substates: Rapid Eye Movement (REM) sleep and Non-rapid Eye Movement (NREM) sleep. NREM sleep is marked by synchronized brain activity and muscle tone loss, while REM sleep is characterized by desynchronized brain activity, muscle atonia, and bursts of eye movements. Nevertheless, the definition of sleep varies across species making the evolutionary origin of distinct sleep states unclear. In orga

…transparency and small size to combine brain-wide imaging

During development, the complex neuronal circuitry of the brain arises from limited information contained in the genome. After the genetic code instructs the birth of neurons, the emergence of brain regions, and the formation of axon tracts, it is believed that neuronal activity plays a critical role in shaping circuits for behavior. Current AI technologies are modeled after the same principle: connections in an initial weight matrix are pruned and strengthened by activity-dependent signals until the network can sufficiently generalize a set of inputs into outputs. Here, we challenge these lea